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Purpose

Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management. This new study will help find out what effects, semaglutide has on people who take the drug and the drug's effect on physical function, body composition, and aging.

Conditions

Eligibility

Eligible Ages
Between 65 Years and 90 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Older than 65 - Have prediabetes or diabetes - BMI ≥ 27.0 kg/m2 - Living independently (not in assisted living or nursing home)

Exclusion Criteria

  • Have heart disease - Have liver disease - Smoke

Study Design

Phase
Phase 4
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Other
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Semaglutide and lifestyle intervention 		Participants will meet with a dietician throughout the study to discuss lifestyle counseling based on recommendation in the diabetes prevention program. They will also be given semaglutide for 20 weeks.
  • Drug: Semaglutide Injectable Product
    Semaglutide will be started at 0.25mg once a week for 4 weeks followed by 0.5mg once weekly for 4 weeks followed by 1.0mg once a week for 12 weeks.
    Other names:
    • Semaglutide and Lifestyle Counseling
  • Behavioral: Lifestyle Counseling
    Lifestyle Counseling will be provided throughout study intervention
Active Comparator
Lifestyle intervention 		Participants will meet with a dietician throughout the study to discuss lifestyle counseling based on recommendation in the diabetes prevention program
  • Behavioral: Lifestyle Counseling
    Lifestyle Counseling will be provided throughout study intervention

More Details

Status
Active, not recruiting
Sponsor
The University of Texas Health Science Center at San Antonio

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.