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Purpose

This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD. Results from this work will provide insight into whether combination interventions utilizing AE and VR have parallel effects on cognition, gait, and neuroplasticity in PD.

Condition

Eligibility

Eligible Ages
Between 18 Years and 85 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Diagnosis of idiopathic PD (ages 18 - 85) in Hoehn and Yahr stages 1 - 3. 2. Subjects need to demonstrate a score of equal to or greater than 23 on the Mini Mental State Examination.

Exclusion Criteria

  1. Subjects with a history of other neurological diseases (i.e. stroke, multiple sclerosis). 2. Subjects with a history of severe cardiopulmonary disease, uncontrolled hypertension, orthostatic hypotension, uncontrolled diabetes, severe osteoporosis. 3. Subjects with a history of PD-specific surgical procedure such as deep brain stimulation etc. 4. Subjects with a history of head injury. 5. Subjects with a history of seizures or epilepsy, 6. Subjects who are currently pregnant 7. Subjects who use of medications that could alter corticomotor excitability or increase risk of seizure 8. Subjects with skull abnormalities, fractures, unexplained, recurring headaches. 9. Subjects who have cognitive or communication impairment that would affect participation.

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Intervention Model Description
This study will utilize a single group, pre-post design
Primary Purpose
Health Services Research
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Combined Aerobic Exercise (AE) and Virtual Reality (VR)-based program 		Individuals diagnosed with PD will participate in AE and VR.
  • Other: Aerobic Exercise
    Participants will perform a 30-minute exercise protocol (5 minutes warm-up and cool-down each and 20 minutes moderate intensity exercise) on a StepOne™ recumbent stepper
  • Device: Virtual Reality
    Participants will interact with the virtual environment and view the gaming environment on a flat-screen TV placed in front of them at a suitable distance. The participants will play four games (50 repetitions/game divided into three blocks with 1-2 minutes rest between blocks), with the order of the games randomized in every session.

Recruiting Locations

UT Health San Antonio- Dept. of Physical Therapy
San Antonio, Texas 78229
Contact:
Anjali Sivaramakrishnan, PT, PhD
210-567-8626
sivaramakris@uthscsa.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center at San Antonio

Study Contact

Detailed Description

In this pilot proof-of-concept study, the study team will recruit 25 individuals with Parkinson's disease who will perform aerobic exercise (AE) followed by virtual reality (VR). The study team will measure the effects of the intervention on dual task performance, clinical measures of gait, cognition, TMS measures and questionnaires pertaining to quality of life.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.