Purpose

PURPOSE: This randomized phase III trial is studying giving oxaliplatin, leucovorin calcium, and fluorouracil together to compare how well they work when given together with or without celecoxib in treating patients with stage III colon cancer previously treated with surgery. RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving oxaliplatin, leucovorin calcium, and fluorouracil is more effective with or without celecoxib in treating colon cancer.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Criteria


1. Requirements for tumor parameters

1. Histologically documented adenocarcinoma of the colon. The gross inferior
(caudad) margin of the primary tumor must lie above the peritoneal reflection
(i.e., patients with rectal cancer are not eligible). Surgeon confirmation that
the entire tumor was above the peritoneal reflection is only required in cases
where it is important to establish if the tumor is a rectal or colon primary.

2. Tumors must have been completely resected. In patients with tumor adherent to
adjacent structures, en bloc R0 resection must be documented in the operative
report or otherwise confirmed by the surgeon. Near or positive radial margin are
not exclusions as long as en bloc resection was performed. Positive proximal
margin or distal margin is an exclusion.

3. Node positive disease (N1 or N2) as designated in AJCC version 7. Either at least
one pathologically confirmed positive lymph node or N1C (defined as tumor
deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or
perirectal tissues without regional lymph node metastases). Patients with
resected stage IV disease are not eligible.

4. No evidence of residual involved lymph node disease or metastatic disease at the
time of registration.

5. Patients with synchronous colon cancers are eligible and staging for
stratification will be based on higher N stage of the more advanced primary
tumor. However, patients with synchronous colon and rectal primary tumors are not
eligible.

2. NSAID use

Patients are ineligible if they plan on regular use of NSAIDs at any dose more than 2
times per week (on average) or aspirin at more than 325 mg at least three times per
week, on average. Low-dose aspirin not exceeding 100 mg/day is permitted. Patients who
agree to stop regular NSAIDs or higher dose aspirin are eligible and no was out period
is required.

3. Patient history

1. No previous or concurrent malignancy, except treated basal cell or squamous cell
cancer of skin, treated in situ cervical cancer, treated lobular or ductal
carcinoma in situ in one breast, or any other cancer for which the patient has
been disease-free for at least 5 years.

2. No neurosensory or neuromotor toxicity ≥ grade 2 at the time of registration.

3. No known allergy to platinum compounds.

4. No prior allergic reaction or hypersensitivity to sulfonamides, celecoxib or
NSAIDs.

5. No history of upper gastrointestinal ulceration, upper gastrointestinal bleeding,
or upper gastrointestinal perforation within the past 3 years. Patients with
ulceration, bleeding or perforation in the lower bowel are not excluded.

6. No symptomatic pulmonary fibrosis or interstitial pneumonitis ≥ grade 2.

7. No cardiac risk factors including:

- Uncontrolled high blood pressure (systolic blood pressure > 150).

- Unstable angina.

- History of documented myocardial infarction or cerebrovascular accident.

- New York Heart Association class III or IV heart failure.

4. Pregancy/nursing status

Non-pregnant and not nursing. Men and women of childbearing potential must agree to
employ adequate contraception for the duration of chemotherapy and for as many as 8
weeks after the completion of chemotherapy due to the unknown teratogenic effects of
FOLFOX on the developing fetus.

5. Age and performance status

1. ECOG performance status 0, 1 or 2.

2. Age at least 18 years.

6. Required initial laboratory values

1. Granulocytes ≥ 1,500/μL

2. Platelet count ≥ 100,000/μL

3. Creatinine ≤ 1.5 times upper limit of normal (ULN)

4. Total Bilirubin ≤ 1.5 times ULN in the absence of Gilbert's disease

5. Direct bilirubin ≤ 1.5 x upper limit of normal for patients with Gilbert's
syndrome

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm A - FOLFOX and placebo (12 treatments)
Patients receive FOLFOX every 2 weeks plus placebo every day for 12 treatments (24 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive placebo alone every day for 3 years total.
  • Drug: 5-fluorouracil
    Patients receive 400 mg/m^2 intravenous bolus then 2400 mg/m^2 continuous intravenous infusion over 46-48 hours.
  • Other: placebo
    Patients receive placebo administered by mouth, once daily.
  • Drug: oxaliplatin
    Patients receive 85 mg/m^2 intravenous over two hours.
  • Drug: leucovorin
    Patients receive 400 mg/m^2 intravenous over two hours.
Experimental
Arm B - FOLFOX and celecoxib (12 treatments)
Patients receive FOLFOX every 2 weeks plus celecoxib every day for 12 treatments (24 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive celecoxib alone every day for 3 years total.
  • Drug: celecoxib
    Patients receive celecoxib 400 mg administered by mouth, once daily.
  • Drug: 5-fluorouracil
    Patients receive 400 mg/m^2 intravenous bolus then 2400 mg/m^2 continuous intravenous infusion over 46-48 hours.
  • Drug: oxaliplatin
    Patients receive 85 mg/m^2 intravenous over two hours.
  • Drug: leucovorin
    Patients receive 400 mg/m^2 intravenous over two hours.
Active Comparator
Arm C - FOLFOX and placebo (6 treatments)
Patients receive FOLFOX every 2 weeks plus placebo every day for 6 treatments (12 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive placebo alone every day for 3 years total.
  • Drug: 5-fluorouracil
    Patients receive 400 mg/m^2 intravenous bolus then 2400 mg/m^2 continuous intravenous infusion over 46-48 hours.
  • Other: placebo
    Patients receive placebo administered by mouth, once daily.
  • Drug: oxaliplatin
    Patients receive 85 mg/m^2 intravenous over two hours.
  • Drug: leucovorin
    Patients receive 400 mg/m^2 intravenous over two hours.
Experimental
Arm D - FOLFOX and celecoxib (6 treatments)
Patients receive FOLFOX every 2 weeks plus celecoxib every day for 6 treatments (12 weeks). Each 2-week period is called a cycle. FOLFOX includes oxaliplatin, leucovorin and 5-FU.Then, patients receive celecoxib alone every day for 3 years total.
  • Drug: celecoxib
    Patients receive celecoxib 400 mg administered by mouth, once daily.
  • Drug: 5-fluorouracil
    Patients receive 400 mg/m^2 intravenous bolus then 2400 mg/m^2 continuous intravenous infusion over 46-48 hours.
  • Drug: oxaliplatin
    Patients receive 85 mg/m^2 intravenous over two hours.
  • Drug: leucovorin
    Patients receive 400 mg/m^2 intravenous over two hours.

More Details

Status
Unknown status
Sponsor
Alliance for Clinical Trials in Oncology

Study Contact

Detailed Description

OUTLINE: This is a multicenter study. Patients are stratified according to number of positive lymph nodes* (1-3 vs 4 or more) and concurrent regular low-dose of aspirin (yes vs no). Patients are randomized to 1 of 4 treatment arms. Please see the "Arms" section for more information. In all arms, treatment with celecoxib or placebo continues for 3 years in the absence of disease progression or unacceptable toxicity. Blood and tissue samples maybe collected for biomarker analysis and pharmacogenomic studies. The primary and secondary objectives for the research study are described below. Primary objective: 1. To compare disease-free survival of patients with stage III colon cancer randomized to standard chemotherapy only FOLFOX or standard chemotherapy FOLFOX with 3 years of celecoxib 400 mg daily. Secondary objectives: 1. To contribute to an international prospective pooled analysis that will compare disease-free survival of patients with stage III colon cancer randomized to 6 treatments of adjuvant FOLFOX chemotherapy or 12 treatments of adjuvant FOLFOX chemotherapy. 2. To compare overall survival of patients with stage III colon cancer randomized to standard chemotherapy only (FOLFOX) or standard chemotherapy (FOLFOX) with 3 years of celecoxib 400 mg daily. 3. To contribute to an international prospective pooled analysis that will compare overall survival of patients with stage III colon cancer randomized to 6 treatments of adjuvant FOLFOX chemotherapy or 12 treatments of adjuvant FOLFOX chemotherapy or 12 treatments of adjuvant FOLFOX chemotherapy. 4. To assess toxicities of celecoxib as maintenance adjuvant therapy in patients with stage III colon cancer. 5. To assess differences in cardiovascular-specific events with celecoxib versus placebo in a population of stage III colon cancer survivors. 6. To evaluate differences in toxicities, particularly cumulative peripheral neuropathy, for patients treated with 6 treatments of FOLFOX compared to those treated with 12 treatments of FOLFOX. After completion of study therapy, patients are followed up every 6 months for up to 6 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.