Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus

Purpose

Hospitalized patients with severe COVID-19 have an increased incidence of insulin resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt type 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19 negative individuals on long-term follow up.

Conditions

  • COVID-19
  • Diabete Mellitus

Eligibility

Eligible Ages
Between 18 Years and 75 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Body Mass index (BMI) < 40 kg/m2

Exclusion Criteria

  • History of diabetes prior to SARS-CoV-2 infection - Took medications used to treat diabetes prior to SARS-CoV-2 infection - History of myocardial infarction or stroke within 6 months - History of major organ system disease prior to COVID-19 infection

Study Design

Phase
Study Type
Observational
Observational Model
Other
Time Perspective
Other

Arm Groups

ArmDescriptionAssigned Intervention
Severe COVID-19 Group Hospitalized in ICU with COVID-19 (PCR positive) and recovered
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested
Mild COVID-19 positive Group COVID-19 positive (by PCR) who recovered from mild COVID-19 and were seen in outpatient clinics or ER with symptoms that did not justify hospitalization.
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested
COVID-19 negative Group COVID-19 negative (by PCR) and seen in outpatient clinics or ER during same time period as Groups I and II.
  • Other: Measure of physiologic parameters
    Participants will have hepatic muscle and adipose tissue insulin sensitivity tested

Recruiting Locations

Texas Diabetes Institute - University Health System
San Antonio, Texas 78207
Contact:
Andrea Hansis-Diarte, MPh
210-567-6691
hansisdiarte@uthscsa.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center at San Antonio

Study Contact

Marzieh Salehi, MD
(210) 567-6691
salehi@uthscsa.edu

Detailed Description

The purpose of this research study is to understand the long-term effects of COVID-19 infection on individuals without any prior history of diabetes. This study will look at several measures of diabetes, such as glycemic control (blood glucose/sugar levels), function of beta cells (cells that make insulin to control sugar), insulin secretion and insulin sensitivity (fasting insulin levels). The following participants will be enrolled: 1) have had COVID-19 infection and were hospitalized and recovered, or 2) have had mild COVID-19 infection and were seen at outpatient clinics or ER and were not required to be hospitalized, or 3) have not had COVID-19 infection but were seen in outpatient clinics or ER during the same time period. The researchers hope to learn the long-term effects of COVID-19 infection in hospitalized patients. Specifically, they will be focusing on the subsequent development of diabetes and associated metabolic disturbances, such as impaired insulin secretion and insulin resistance. A relationship between COVID-19 and diabetes needs to be investigated.