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The Effects of Bariatric Surgeries on Glucose Metabolism
The University of Texas Health Science Center at San Antonio
Post Bariatric Surgery
Gastric Bypass
Sleeve Gastrectomy
Hypoglycemia After Gastric Bypass
The purpose of this study is learn the effect of gastric bypass surgery and sleeve
gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after
eating. expand
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating. Type: Interventional Start Date: Jul 2015 |
SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis
The University of Texas Health Science Center at San Antonio
Type 2 Diabetes
Type 1 Diabetes
In this study, we will test the hypothesis that distinct mechanisms account for the
SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic)
glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and
that the increases in ketone production and... expand
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. We will conduct five distinct experiments to test this hypothesis in patients with T2D and T1D. STUDY 1: To examine the effect of empagliflozin versus empagliflozin/pancreatic clamp on EGP (6,6, D2-glucose), gluconeogenesis (D2O), lipolysis (U-2H-glycerol), ketogenesis (13C-palmitate conversion to 3-betahydroxybuyrate), and norepinephrine turnover (3H-NE) in type 2 diabetes subjects. STUDY 2. To examine the role of the SNS on the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D by comparing the effect of empagliflozin versus empagliflozin plus propranolol. STUDY 3. To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals. STUDY 4. To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects). STUDY 5. To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T1D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects). Type: Interventional Start Date: Oct 2023 |
Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
Rapamycin Holdings, Inc. dba Emtora Biosciences
Familial Adenomatous Polyposis
Patients with Familial Adenomatous Polyposis (FAP) who are undergoing endoscopic
surveillance will be given Encapsulated Rapamycin (eRapa) at one of three escalating
doses/schedules for 12 months with the aim of reducing polyp burden. expand
Patients with Familial Adenomatous Polyposis (FAP) who are undergoing endoscopic surveillance will be given Encapsulated Rapamycin (eRapa) at one of three escalating doses/schedules for 12 months with the aim of reducing polyp burden. Type: Interventional Start Date: Jan 2021 |
Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma,...
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm
Malignant Solid Neoplasm
Recurrent Ependymoma
Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Hepatoblastoma
This phase II Pediatric MATCH treatment trial studies how well ensartinib works in
treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with
ALK or ROS1 genomic alterations that have come back (recurrent) or does not respond to
treatment (refractory) and may have spread... expand
This phase II Pediatric MATCH treatment trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or does not respond to treatment (refractory) and may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Ensartinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Type: Interventional Start Date: Apr 2018 |
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
ECOG-ACRIN Cancer Research Group
Gliosarcoma
Recurrent Glioblastoma
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic
resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for
early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI
may help evaluate changes in the blood... expand
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment. Type: Interventional Start Date: Jul 2017 |
Neurobiological Similarities of Tinnitus and PTSD
The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Tinnitus
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as
perceived loudness and discomfort. It is important to understand how tinnitus-related
distress and PTSD negatively interact together, in order to develop more effective
therapeutic approaches. Understanding symptoms... expand
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as perceived loudness and discomfort. It is important to understand how tinnitus-related distress and PTSD negatively interact together, in order to develop more effective therapeutic approaches. Understanding symptoms and neurobiological mechanisms using functional magnetic resonance imaging (fMRI), can lead to the necessary knowledge to develop effective interventions for individuals who suffer from both conditions. Type: Observational Start Date: Feb 2021 |
Vfib by ECG or Echo During Cardiac Arrest
Romolo Gaspari
Cardiac Arrest
The goal of this study is to measure survival rates associated with patients presenting
in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic
rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and
echocardiographic rhythm is the rhythm visualized... expand
The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualized on bedside ultrasound. Specifically, we will categorize patients based on identical rhythms and dichotomous rhythms with an interest in outcomes in the patient group where their echocardiographic and electrographic rhythms do not match. This is important as current ACLS protocols use electrocardiographic rhythms to determine therapy but limited research implies that therapeutic decisions based on echocardiographic rhythm may produce increased survival. This study will occur during emergency department resuscitation of patients presenting in cardiac arrest. Patients presenting to the emergency department after cardiac arrest will undergo standard resuscitation based on ACLS protocols. Ultrasound imaging will be performed as soon as possible after the patient arrives and digitally recorded, as is currently the standard of care at the institute. Simultaneous recording of the ECG rhythm strip will occur as well. This will be repeated for as many pauses in CPR as is warranted. Each site will record data based on the Utstein nomenclature including patient demographics, arrest details and survival outcomes. Ultrasound images and ECG recordings will be de-identified and submitted to a central database. Data will be uploaded into a centralized database. Statistical analysis will analyze outcomes based on echocardiographic and sonographic findings. Our aim is to measure the survival benefit of treating out of hospital cardiac arrest using echocardiographic rhythm instead of electrocardiographic rhythm. Type: Observational Start Date: Sep 2021 |
Study in Parkinson Disease of Exercise
Northwestern University
Parkinson Disease
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance
treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease
Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage
Parkinson disease. 370 participants will... expand
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 months in among persons who have not initiated medication for Parkinson Disease (PD) when they perform high-intensity endurance treadmill exercise. Type: Interventional Start Date: Aug 2021 |
Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD
The University of Texas Health Science Center at San Antonio
Parkinson's Disease
This project will provide preliminary data on the feasibility and effects of exercise and
VR on motor behavior and neuroplasticity in PD. Results from this work will provide
insight into whether combination interventions utilizing AE and VR have parallel effects
on cognition, gait, and neuroplasticity... expand
This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD. Results from this work will provide insight into whether combination interventions utilizing AE and VR have parallel effects on cognition, gait, and neuroplasticity in PD. Type: Interventional Start Date: Nov 2022 |
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
Children's Oncology Group
Hematopoietic Cell Transplantation Recipient
Leukemia
Solid Tumor
This clinical trial keeps track of and collects follow-up information from patients who
are currently enrolled on or have participated in a Children's Oncology Group study.
Developing a way to keep track of patients who have participated in Children's Oncology
Group studies may allow doctors learn... expand
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life. Type: Observational Start Date: Jul 2008 |
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Massachusetts General Hospital
Cognitive Impairment
Dementia
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is
an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking
and memory problems. Alzheimer's disease and other dementias leave signatures on brain
scans or in the blood called biomarkers.... expand
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss. Age-related problems in thinking and memory represent some of the greatest risks to public health in the US and globally. Diseases that affect small blood vessels in the brain have been shown to be major contributors to these changes. However, research and patient care can be held back by limited biomarkers that identify who should be treated. The MarkVCID Consortium includes 17 US medical centers, a Coordinating Center, an External Advisory Committee, and NIH leadership. Data and biospecimens collected as part of this research study will be stored in a research database and biorepositories, so that researchers can use this information to study brain function. Type: Observational Start Date: Sep 2021 |
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The University of Texas Health Science Center at San Antonio
Stress Disorders, Post-Traumatic
The goal of this clinical trial is to compare the combination of Massed Prolonged
Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an
injection of a local anesthetic into the front of the neck) with Massed Prolonged
Exposure and a sham injection in a sample of military... expand
The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of military service members or retirees with PTSD. The main questions it aims to answer are: (1) Does the addition of an SGB improve treatment outcomes associated with Massed PE and (2) Do differences in psychophysiological arousal during the exposure portion of treatment help explain treatment outcomes for PTSD. Participants will receive ten 90-minute session of Massed PE. Between the first and second Massed PE sessions, half of the participants will receive a SGB, and half will receive a sham SGB. Type: Interventional Start Date: Feb 2024 |
A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic,...
Tvardi Therapeutics, Incorporated
Hepatocellular Carcinoma
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability
of TTI-101 orally administered as a single agent to participants with locally advanced or
metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum
tolerated dose (MTD) and/or recommended... expand
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent to participants with locally advanced or metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of TTI-101 as a single agent. The primary objectives of Cohort A Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent at the RP2D to participants with locally advanced or metastatic, and unresectable HCC and to assess the preliminary efficacy of TTI-101 as a single agent in participants with locally advanced or metastatic, and unresectable HCC. The secondary objectives of Cohort A Phase 2 are to assess response, progression, survival, and pharmacokinetics. The primary objectives of Cohorts B and C Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) to participants with locally advanced or metastatic, or unresectable HCC and to determine the MTD and/or RP2D of TTI-101 when used in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C). The primary objectives of Cohorts B and C Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) at the RP2D to participants with locally advanced or metastatic, and unresectable HCC and to assess the preliminary efficacy of TTI-101 in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) to participants with locally advanced or metastatic, and unresectable HCC. The secondary objectives of Cohorts B and C Phase 2 are to assess response, progression, survival, and pharmacokinetics. Type: Interventional Start Date: Mar 2023 |
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
NRG Oncology
Metastatic Malignant Neoplasm in the Brain
This phase III trial compares the addition of stereotactic radiosurgery before or after
surgery in treating patients with cancer that has spread to the brain (brain metastases).
Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of
radiation only to the small areas... expand
This phase III trial compares the addition of stereotactic radiosurgery before or after surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation only to the small areas of cancer in the brain and avoids the surrounding normal brain tissue. Surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. Type: Interventional Start Date: Aug 2022 |
Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma
The University of Texas Health Science Center at San Antonio
Carcinoma, Hepatocellular
This is an observational, prospective cohort study that will recruit a diverse sample of
84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma
(HCC) at the UT Health Cancer Center in San Antonio. This study uses geriatric assessment
tools with participants 65 years... expand
This is an observational, prospective cohort study that will recruit a diverse sample of 84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (HCC) at the UT Health Cancer Center in San Antonio. This study uses geriatric assessment tools with participants 65 years and older and collects adverse events and exploratory markers of aging for all participants. Type: Observational Start Date: Sep 2019 |
Transformative Research in Diabetic Nephropathy
University of Pennsylvania
Diabetic Nephropathies
Diabetic Glomerulosclerosis
This is a prospective, observational, cohort study of patients with a clinical diagnosis
of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to
collect, process, and study kidney tissue and to harvest blood, urine and genetic
materials to elucidate molecular pathways and... expand
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol. Type: Observational Start Date: Dec 2016 |
Patient-derived Organoid Model and Circulating Tumor Cells for Treatment Response of Lung Cancer
The University of Texas Health Science Center at San Antonio
Lung Neoplasm
Create a living biobank of PDOs from Stage I-III lung cancer patients. expand
Create a living biobank of PDOs from Stage I-III lung cancer patients. Type: Observational Start Date: Oct 2018 |
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
The University of Texas Health Science Center at San Antonio
Atrophy of Muscle Due to Disuse
Rehabilitation
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral
leg disuse (Phase 1), immediately followed by 14 days of bilateral leg rehabilitation
(Phase 2). The investigators will recruit cohorts of healthy middle-aged men and women to
address their aims:
- Demonstrate... expand
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 14 days of bilateral leg rehabilitation (Phase 2). The investigators will recruit cohorts of healthy middle-aged men and women to address their aims: - Demonstrate the sex-specific effects of skeletal muscle disuse (Phase 1) - Identify key molecular determinates of susceptibility of skeletal muscle atrophy (Phase 1) - Map the early, sex-specific molecular time-course of rehabilitation (Phase 2) - Determine if disused and healthy muscle respond similarly to exercise (Phase 2) Healthy, middle-age men and post-menopausal women (50-65 years) will be recruited from the greater Houston/Galveston area. This under-represented research demographic demonstrate few negative metabolic or phenotypic signs of advanced age, but are at increased risk of being hospitalized and experiencing accelerated loss of lean mass and muscle function that parallels a much older population. The goal of this study is to characterize phenotypic and molecular skeletal muscle changes in middle-aged men and women during critical periods of disuse and rehabilitation and ultimately direct the development of targeted and effective prevention and treatment strategies. Type: Interventional Start Date: Aug 2021 |
Chromosome 18 Clinical Research Center
The University of Texas Health Science Center at San Antonio
Chromosome Aberrations
Growth Hormone Deficiency
Hypomyelination
Our vision, that of the researchers at the University of Texas Health Science Center at
San Antonio, is that every person with a chromosome 18 abnormality will have an
autonomous and healthy life. Our mission is to provide families affected by chromosome 18
abnormalities with comprehensive medical... expand
Our vision, that of the researchers at the University of Texas Health Science Center at San Antonio, is that every person with a chromosome 18 abnormality will have an autonomous and healthy life. Our mission is to provide families affected by chromosome 18 abnormalities with comprehensive medical and educational information. Our goals are to provide definitive medical and education resources for the families of individuals with chromosome 18 abnormalities; perform and facilitate groundbreaking clinical and basic research relating to the syndromes of chromosome 18; and to provide treatments to help these individuals overcome the effects of their chromosome abnormality. Type: Observational Start Date: Sep 1993 |
Genomic Predictors of Recurrent Pregnancy Loss
Yale University
Recurrent Pregnancy Loss
The overall goals of this proposal are to determine the genetic architecture of recurrent
pregnancy loss (RPL) and to discover genomic predictors of RPL. expand
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL. Type: Observational Start Date: Sep 2021 |
Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia A
Washington Institute for Coagulation
Hemophilia A
The investigators propose to study longitudinal joint and bone density changes in
patients with severe Hemophilia A. Per current standard of care, most patients are on
prophylactic FVIII replacement therapy intravenously several times weekly with a goal of
keeping the trough >1% FVIII. Recent phase... expand
The investigators propose to study longitudinal joint and bone density changes in patients with severe Hemophilia A. Per current standard of care, most patients are on prophylactic FVIII replacement therapy intravenously several times weekly with a goal of keeping the trough >1% FVIII. Recent phase 3 data suggest superior bleed protection with emicizumab prophylaxis every 1-2 weeks. It is the purpose of this study to longitudinally assess joint health and bone density over 3 years and to compare the effect of routine factor VIII prophylaxis with emicizumab prophylaxis. Type: Observational Start Date: Apr 2019 |
Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy
The University of Texas Health Science Center at San Antonio
Myomectomy; Surgical Blood Loss
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood
loss when compared to vasopressin alone, which is our current practice at this time. The
study will be double-blinded with neither the patient nor the researcher knowing whether
the placebo or the misoprostol was... expand
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time. The study will be double-blinded with neither the patient nor the researcher knowing whether the placebo or the misoprostol was given. We will monitor patients for decrease in hemoglobin and hematocrit, need for transfusion, and operative time among other measures of perioperative morbidity to see if the addition of misoprostol makes a significant difference. We will also observe patients to see if there are any side effects of misoprostol that make its use undesirable. Type: Interventional Start Date: Oct 2016 |
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