Search Clinical Trials
Sponsor Condition of Interest |
---|
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Yale University
Intracerebral Hemorrhage
Atrial Fibrillation
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite
outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with
recent ICH and atrial fibrillation (AF).
Secondary Aim: To determine if apixaban, compared... expand
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale. Type: Interventional Start Date: Jan 2020 |
Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma,...
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm
Malignant Solid Neoplasm
Recurrent Ependymoma
Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Hepatoblastoma
This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients
with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic
alterations that have come back (recurrent) or does not respond to treatment (refractory) and... expand
This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or does not respond to treatment (refractory) and may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Ensartinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Type: Interventional Start Date: Apr 2018 |
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Massachusetts General Hospital
Cognitive Impairment
Dementia
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an
NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and
memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or... expand
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss. Age-related problems in thinking and memory represent some of the greatest risks to public health in the US and globally. Diseases that affect small blood vessels in the brain have been shown to be major contributors to these changes. However, research and patient care can be held back by limited biomarkers that identify who should be treated. The MarkVCID Consortium includes 17 US medical centers, a Coordinating Center, an External Advisory Committee, and NIH leadership. Data and biospecimens collected as part of this research study will be stored in a research database and biorepositories, so that researchers can use this information to study brain function. Type: Observational Start Date: Sep 2021 |
Endurance Exercise & Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in PD
The University of Texas Health Science Center at San Antonio
Parkinson Disease
This study aims to determine the effects of aerobic exercise as a primer to add-on virtual
reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability
of brain to adapt in structure and function) in individuals with Parkinson's disease (PD).... expand
This study aims to determine the effects of aerobic exercise as a primer to add-on virtual reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability of brain to adapt in structure and function) in individuals with Parkinson's disease (PD). This study will utilize two groups - one group will receive the exercise and VR, while the other group will receive stretching exercise and VR over eight weeks. The study team will administer outcomes at baseline, post-intervention (8 weeks) and follow-up (6 weeks after post-assessment). Type: Interventional Start Date: Feb 2024 |
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The University of Texas Health Science Center at San Antonio
Stress Disorders, Post-Traumatic
The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure
(PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a
local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham
injection... expand
The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of military service members or retirees with PTSD. The main questions it aims to answer are: (1) Does the addition of an SGB improve treatment outcomes associated with Massed PE and (2) Do differences in psychophysiological arousal during the exposure portion of treatment help explain treatment outcomes for PTSD. Participants will receive ten 90-minute session of Massed PE. Between the first and second Massed PE sessions, half of the participants will receive a SGB, and half will receive a sham SGB. Type: Interventional Start Date: Feb 2024 |
A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic,...
Tvardi Therapeutics, Incorporated
Hepatocellular Carcinoma
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability of
TTI-101 orally administered as a single agent to participants with locally advanced or
metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum
tolerated... expand
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent to participants with locally advanced or metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of TTI-101 as a single agent. The primary objectives of Cohort A Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent at the RP2D to participants with locally advanced or metastatic, and unresectable HCC and to assess the preliminary efficacy of TTI-101 as a single agent in participants with locally advanced or metastatic, and unresectable HCC. The secondary objectives of Cohort A Phase 2 are to assess response, progression, survival, and pharmacokinetics. The primary objectives of Cohorts B and C Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) to participants with locally advanced or metastatic, or unresectable HCC and to determine the MTD and/or RP2D of TTI-101 when used in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C). The primary objectives of Cohorts B and C Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) at the RP2D to participants with locally advanced or metastatic, and unresectable HCC and to assess the preliminary efficacy of TTI-101 in combination with pembrolizumab therapy (Cohort B) and in combination with atezolizumab and bevacizumab therapy (Cohort C) to participants with locally advanced or metastatic, and unresectable HCC. The secondary objectives of Cohorts B and C Phase 2 are to assess response, progression, survival, and pharmacokinetics. Type: Interventional Start Date: Mar 2023 |
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
NRG Oncology
Metastatic Malignant Neoplasm in the Brain
This phase III trial compares the addition of stereotactic radiosurgery before or after
surgery in treating patients with cancer that has spread to the brain (brain metastases).
Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of
radiation... expand
This phase III trial compares the addition of stereotactic radiosurgery before or after surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation only to the small areas of cancer in the brain and avoids the surrounding normal brain tissue. Surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. Type: Interventional Start Date: Aug 2022 |
Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma
The University of Texas Health Science Center at San Antonio
Carcinoma, Hepatocellular
This is an observational, prospective cohort study that will recruit a diverse sample of 84
participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (HCC)
at the UT Health Cancer Center in San Antonio. This study uses geriatric assessment tools... expand
This is an observational, prospective cohort study that will recruit a diverse sample of 84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (HCC) at the UT Health Cancer Center in San Antonio. This study uses geriatric assessment tools with participants 65 years and older and collects adverse events and exploratory markers of aging for all participants. Type: Observational Start Date: Sep 2019 |
Transformative Research in Diabetic Nephropathy
University of Pennsylvania
Diabetic Nephropathies
Diabetic Glomerulosclerosis
This is a prospective, observational, cohort study of patients with a clinical diagnosis of
diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect,
process, and study kidney tissue and to harvest blood, urine and genetic materials to
elucidate... expand
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol. Type: Observational Start Date: Dec 2016 |
Patient-derived Organoid Model and Circulating Tumor Cells for Treatment Response of Lung Cancer
The University of Texas Health Science Center at San Antonio
Lung Neoplasm
Create a living biobank of PDOs from Stage I-III lung cancer patients.
expand
Create a living biobank of PDOs from Stage I-III lung cancer patients. Type: Observational Start Date: Oct 2018 |
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
The University of Texas Health Science Center at San Antonio
Atrophy of Muscle Due to Disuse
Rehabilitation
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg
disuse (Phase 1), immediately followed by 14 days of bilateral leg rehabilitation (Phase 2).
The investigators will recruit cohorts of healthy middle-aged men and women to address their... expand
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 14 days of bilateral leg rehabilitation (Phase 2). The investigators will recruit cohorts of healthy middle-aged men and women to address their aims: - Demonstrate the sex-specific effects of skeletal muscle disuse (Phase 1) - Identify key molecular determinates of susceptibility of skeletal muscle atrophy (Phase 1) - Map the early, sex-specific molecular time-course of rehabilitation (Phase 2) - Determine if disused and healthy muscle respond similarly to exercise (Phase 2) Healthy, middle-age men and post-menopausal women (50-65 years) will be recruited from the greater Houston/Galveston area. This under-represented research demographic demonstrate few negative metabolic or phenotypic signs of advanced age, but are at increased risk of being hospitalized and experiencing accelerated loss of lean mass and muscle function that parallels a much older population. The goal of this study is to characterize phenotypic and molecular skeletal muscle changes in middle-aged men and women during critical periods of disuse and rehabilitation and ultimately direct the development of targeted and effective prevention and treatment strategies. Type: Interventional Start Date: Aug 2021 |
Chromosome 18 Clinical Research Center
The University of Texas Health Science Center at San Antonio
Chromosome Aberrations
Growth Hormone Deficiency
Hypomyelination
Our vision, that of the researchers at the University of Texas Health Science Center at San
Antonio, is that every person with a chromosome 18 abnormality will have an autonomous and
healthy life. Our mission is to provide families affected by chromosome 18 abnormalities with... expand
Our vision, that of the researchers at the University of Texas Health Science Center at San Antonio, is that every person with a chromosome 18 abnormality will have an autonomous and healthy life. Our mission is to provide families affected by chromosome 18 abnormalities with comprehensive medical and educational information. Our goals are to provide definitive medical and education resources for the families of individuals with chromosome 18 abnormalities; perform and facilitate groundbreaking clinical and basic research relating to the syndromes of chromosome 18; and to provide treatments to help these individuals overcome the effects of their chromosome abnormality. Type: Observational Start Date: Sep 1993 |
SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis
The University of Texas Health Science Center at San Antonio
Type 2 Diabetes
Type 1 Diabetes
The purpose of this study is to examine the effect of empagliflozin, with and without
pancreatic clamp, on endogenous (hepatic) glucose production (EGP, or 6,6, D2-glucose),
gluconeogenesis (D2O), lipolysis (U-2H-glycerol), ketogenesis (13C-palmitate conversion to
3-betahydroxybutyrate),... expand
The purpose of this study is to examine the effect of empagliflozin, with and without pancreatic clamp, on endogenous (hepatic) glucose production (EGP, or 6,6, D2-glucose), gluconeogenesis (D2O), lipolysis (U-2H-glycerol), ketogenesis (13C-palmitate conversion to 3-betahydroxybutyrate), and norepinephrine turnover (3H-NE) in type 2 diabetes subjects. Type: Interventional Start Date: Oct 2023 |
Comparing Antipsychotic Medications in LBD Over Time
The University of Texas Health Science Center at San Antonio
Parkinson's Disease Psychosis
Dementia With Lewy Bodies
The primary objective of this study is to determine whether treatment with pimavanserin or
quetiapine is associated with a greater improvement in psychosis when used in a routine
clinical setting to treat hallucinations and/or delusions due to Parkinson's disease (PD) or
dementia... expand
The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and/or delusions due to Parkinson's disease (PD) or dementia with Lewy bodies (DLB) - collectively referred to as Lewy body disease (LBD). Type: Interventional Start Date: Apr 2022 |
Vertebral Marrow Attention Trial (VMAT)
The University of Texas Health Science Center at San Antonio
Lung Cancer
The purpose of this study is to see whether designing radiation to spare the vertebral bone
marrow can limit the rates of lymphopenia during standard of care chemoradiation therapy and
in the time to count recovery in the ensuing weeks. Secondary endpoints will examine whether... expand
The purpose of this study is to see whether designing radiation to spare the vertebral bone marrow can limit the rates of lymphopenia during standard of care chemoradiation therapy and in the time to count recovery in the ensuing weeks. Secondary endpoints will examine whether this leads to improved disease control whether this is predictive of improved clinical outcomes such as rates of local recurrence (LR), metastasis free survival (MFS), overall survival (OS), and progression free survival (PFS) which will be followed prospectively up to 5 years. Type: Interventional Start Date: Sep 2022 |
Neurobiological Similarities of Tinnitus and PTSD
The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Tinnitus
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as
perceived loudness and discomfort. It is important to understand how tinnitus-related
distress and PTSD negatively interact together, in order to develop more effective
therapeutic approaches.... expand
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as perceived loudness and discomfort. It is important to understand how tinnitus-related distress and PTSD negatively interact together, in order to develop more effective therapeutic approaches. Understanding symptoms and neurobiological mechanisms using functional magnetic resonance imaging (fMRI), can lead to the necessary knowledge to develop effective interventions for individuals who suffer from both conditions. Type: Observational Start Date: Feb 2021 |
Genomic Predictors of Recurrent Pregnancy Loss
Yale University
Recurrent Pregnancy Loss
The overall goals of this proposal are to determine the genetic architecture of recurrent
pregnancy loss (RPL) and to discover genomic predictors of RPL.
expand
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL. Type: Observational Start Date: Sep 2021 |
Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases
Plus Therapeutics
Leptomeningeal Metastasis
This is an open-label Phase I clinical study that will administer a single dose of 186RNL via
intraventricular catheter for treatment of Leptomeningeal Metastases (LM).
expand
This is an open-label Phase I clinical study that will administer a single dose of 186RNL via intraventricular catheter for treatment of Leptomeningeal Metastases (LM). Type: Interventional Start Date: Dec 2021 |
4D CBCT and Intrafractional Imaging for the Determination of the Most Representative 4D Simulation Planning...
The University of Texas Health Science Center at San Antonio
Cancer of Lung
The researchers plan to investigate two ways of visualizing and planning to account for the
respiratory motion which takes place while treating lung tumors with radiation therapy. The
researchers will determine if a traditional snapshot (free-breathing) CT or a longer-lasting... expand
The researchers plan to investigate two ways of visualizing and planning to account for the respiratory motion which takes place while treating lung tumors with radiation therapy. The researchers will determine if a traditional snapshot (free-breathing) CT or a longer-lasting CT encompassing the breathing cycle better matches a patient's breathing during treatment. Type: Interventional Start Date: Aug 2021 |
Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia A
Washington Institute for Coagulation
Hemophilia A
The investigators propose to study longitudinal joint and bone density changes in patients
with severe Hemophilia A. Per current standard of care, most patients are on prophylactic
FVIII replacement therapy intravenously several times weekly with a goal of keeping the
trough... expand
The investigators propose to study longitudinal joint and bone density changes in patients with severe Hemophilia A. Per current standard of care, most patients are on prophylactic FVIII replacement therapy intravenously several times weekly with a goal of keeping the trough >1% FVIII. Recent phase 3 data suggest superior bleed protection with emicizumab prophylaxis every 1-2 weeks. It is the purpose of this study to longitudinally assess joint health and bone density over 3 years and to compare the effect of routine factor VIII prophylaxis with emicizumab prophylaxis. Type: Observational Start Date: Apr 2019 |
Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy
The University of Texas Health Science Center at San Antonio
Myomectomy; Surgical Blood Loss
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss
when compared to vasopressin alone, which is our current practice at this time. The study
will be double-blinded with neither the patient nor the researcher knowing whether the
placebo... expand
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time. The study will be double-blinded with neither the patient nor the researcher knowing whether the placebo or the misoprostol was given. We will monitor patients for decrease in hemoglobin and hematocrit, need for transfusion, and operative time among other measures of perioperative morbidity to see if the addition of misoprostol makes a significant difference. We will also observe patients to see if there are any side effects of misoprostol that make its use undesirable. Type: Interventional Start Date: Oct 2016 |
The Effects of Bariatric Surgeries on Glucose Metabolism
The University of Texas Health Science Center at San Antonio
Post Bariatric Surgery
Gastric Bypass
Sleeve Gastrectomy
Hypoglycemia After Gastric Bypass
The purpose of this study is learn the effect of gastric bypass surgery and sleeve
gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after
eating.
expand
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating. Type: Interventional Start Date: Jul 2015 |
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
ECOG-ACRIN Cancer Research Group
Gliosarcoma
Recurrent Glioblastoma
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic
resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for
early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may
help... expand
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment. Type: Interventional Start Date: Jul 2017 |
Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer
The University of Texas Health Science Center at San Antonio
Hepatocellular Cancer
The PI is studying if sorafenib/hydroxychloroquine (HCQ) will have improved efficacy when
compared to sorafenib alone and in patients progressing of sorafenib the addition of HCQ
would lead to disease stability in patients with advanced hepatocellular cancer (HCC).
expand
The PI is studying if sorafenib/hydroxychloroquine (HCQ) will have improved efficacy when compared to sorafenib alone and in patients progressing of sorafenib the addition of HCQ would lead to disease stability in patients with advanced hepatocellular cancer (HCC). Type: Interventional Start Date: Feb 2017 |
Vfib by ECG or Echo During Cardiac Arrest
Romolo Gaspari
Cardiac Arrest
The goal of this study is to measure survival rates associated with patients presenting in
cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm.
Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm... expand
The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualized on bedside ultrasound. Specifically, we will categorize patients based on identical rhythms and dichotomous rhythms with an interest in outcomes in the patient group where their echocardiographic and electrographic rhythms do not match. This is important as current ACLS protocols use electrocardiographic rhythms to determine therapy but limited research implies that therapeutic decisions based on echocardiographic rhythm may produce increased survival. This study will occur during emergency department resuscitation of patients presenting in cardiac arrest. Patients presenting to the emergency department after cardiac arrest will undergo standard resuscitation based on ACLS protocols. Ultrasound imaging will be performed as soon as possible after the patient arrives and digitally recorded, as is currently the standard of care at the institute. Simultaneous recording of the ECG rhythm strip will occur as well. This will be repeated for as many pauses in CPR as is warranted. Each site will record data based on the Utstein nomenclature including patient demographics, arrest details and survival outcomes. Ultrasound images and ECG recordings will be de-identified and submitted to a central database. Data will be uploaded into a centralized database. Statistical analysis will analyze outcomes based on echocardiographic and sonographic findings. Our aim is to measure the survival benefit of treating out of hospital cardiac arrest using echocardiographic rhythm instead of electrocardiographic rhythm. Type: Observational Start Date: Sep 2021 |
- Previous
- Next